Behandlung von Opioidsucht - Eine Übersicht
Behandlung von Opioidsucht - Eine Übersicht
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Physical dependence is manifested by withdrawal symptoms after abrupt discontinuation of a drug or upon administration of an antagonist. Physical dependence and/or tolerance are not unusual during chronic opioid therapy.
Methadone should be given with caution and the initial dose reduced rein certain patients, such as the elderly and debilitated and those with severe impairment of hepatic or renal function, hypothyroidism, Addison's disease, prostatic hypertrophy, or urethral stricture.
Accidental or deliberate ingestion by a child may cause respiratory depression that can result rein death. Patients and caregivers should be instructed to keep methadone in a secure place out of the reach of children and to discard unused methadone rein such a way that individuals other than the patient for whom it welches originally prescribed will not come hinein contact with the drug.
Selection of patients for treatment with methadone should be governed by the same principles that apply to the use of other opioids (Teich INDICATIONS AND USAGE).
Excretion – The elimination of methadone is mediated by extensive biotransformation, followed by renal and fecal excretion. Published reports indicate that after multiple dose administration the Am ende gelegen half-life (T1/2) was highly variable and ranged between 8 to 59 hours hinein different studies.
Antibiotics, such as rifampin and rifabutin. These drugs can cause methadone to stop working. This could result in withdrawal symptoms. Your doctor may change your dosage of methadone as needed.
Methadone is also used to manage drug addiction. If you have an addiction to another opioid, your doctor may give you methadone to prevent you from having severe withdrawal symptoms.
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The initial methadone dose should be administered, under supervision, when there are no signs of sedation or intoxication, and the patient shows symptoms of withdrawal. Initially, a single dose of 20 to 30 Magnesium of methadone will often Beryllium sufficient to suppress withdrawal symptoms. The initial dose should not exceed 30 Magnesium. If same-day dosing adjustments are to Beryllium made, the patient should be asked to wait 2 to 4 hours for further evaluation, when peak levels have been reached. An additional 5 to 10 Magnesium of methadone may Beryllium provided if withdrawal symptoms have not been suppressed or if symptoms reappear.
Patients and their caregivers should Beryllium advised to discard unused methadone in such a way that individuals other than the patient for whom it was originally prescribed will not come rein contact with the drug.
Antibiotics, such as clarithromycin and erythromycin. Taking these drugs with methadone may cause increased drowsiness and slowed breathing. Your doctor might adjust your dosage of methadone, depending on how severe your side effects are.
For people with a head injury: This drug may cause increased pressure hinein your brain. This can raise your risk of complications or cause death.
Examples of benzodiazepines include lorazepam, clonazepam, and alprazolam. These drugs should only be used with methadone when other drugs don’t work well enough.
For children: The safety and effectiveness of this drug haven’t been established hinein children. It shouldn’t be used rein children younger than 18 years. Children World health organization accidentally take this drug have a high risk of death from overdosing.